| Since our formation in 1989, we have developed and diversified into all areas of carbohydrate research, synthesis and analysis. We have a range of over 500 catalogue products plus carbohydrate building blocks and combinatorial libraries. At the same time we retain a flexible approach to tackling new projects and challenges in the areas of carbohydrate chemistry and biology.
Oligosaccharides. We have a unique range of simple and complex oligosaccharides that have been obtained by synthesis, isolation and degradation. They include O-linked structures, blood group A,B,O and Lewis antigens, core structures and sialylated compounds. We specialise too in a range of antigens with the terminal Gala1-3Gal (Galili) determinant. We are developing an unrivalled range of complex N-linked structures and offer many disaccharides and sulphated sugars derived from glycosaminoglycans.
Glycoconjugates. We have developed an extensive range of neoglycoproteins, neoglycolipids and biotinylated sugars using proprietary linker technology and can offer several linker sugar combinations with different chain lengths. We can also make affinity matrices using this and derived techniques to suit customer requirements.
Carbohydrate Building Blocks. We can supply an extensive range of modified carbohydrates that can be used for coupling reactions and complex syntheses to save time in customer work programmes. These products include trichloroacetimidates, thioglycosides, glycals, amino sugars and carboxylic acids.
Carbohydrate-based libraries. We are able to offer libraries for combinatorial chemistry. These ranges include libraries based on 5 and 6 membered carbohydrate scaffolds, nucleoside analogues, plus terpene, steroid and alkaloid glycosides.
Analytical Services. Our analytical service covers all aspects of biomedical and food carbohydrates. For glycoproteins we offer a full glycosylation service including monosaccharide composition, oligosaccharide profiling and sequencing, and molecular mass by mass spectroscopy. For polysaccharides, methylation and fragment analysis by NMR spectroscopy can be provided. Other services include analysis by HPLC and electrophoresis.
Dextra can also offer services related to drug development including stability trials to ICH guidelines and method validation for both API and formulated products.
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